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The activation of the aforementioned non-canonical TGF--mediated signaling cascades have been implicated in the pathogenesis of fibrosis and fibrotic diseases including renal fibrosis, liver fibrosis, systemic sclerosis and osteoarthritis (107, 108)

The liberated L-carnitine immediately goes to work binding to long-chain fatty acids, creating acyl-carnitine, and pulling them into the beta-oxidation cycle to produce ATP