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2) and the MM-like expression derived from our formulation clarify that phosphorylation and -arrestin binding are the two main processes responsible for shaping a drug tolerance (a suppressed downstream signaling at high agonist concentration), a dose-response widely observed in biochemical assays (Fig

Adv Exp Med Biol 2017

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In chondrocyte cultures, GHK-Cu increased the expression of type II collagen, the main structural protein of hyaline cartilage, as well as aggrecan, the most important proteoglycan for the compressive resistance of articular cartilage