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Common side effects associated with B12 supplementation include: Local injection site reactions (for intramuscular preparations): Pain, redness, or swelling at the injection site Mild bruising or tenderness Itching localised to the injection area These reactions are usually self-limiting and resolve within 2448 hours

doi: 10.1080/07315724.1993.10718330

36 In the light of the other results, we expected an increased TNF- level to be associated with beneficial response and an increased IL-1 and IL-6 levels to be associated with nonresponse

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