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Smad-dependent and Smad-independent pathways in TGF family signalling

HSCs, the primary producers of ECM, play an indispensable role in the pathogenesis of liver fibrosis ( The pathogenesis of liver fibrosis is complex, with sustained HSC activation and ECM deposition due to chronic liver injury being major contributors ( in vitro and animal models has revealed multiple pathways by which glycyrrhizin inhibits HSC activation

Coumarin demonstrated a consistent decrease following the intervention, with a fold change of 0.40 (logFC = 1.31)

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