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in ( g ) significance tested by two-sided Mann-Whitney

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Conversely, the downregulation of SIRT1 has been shown to activate the NLRP3 inflammasome, leading to the release of pro-inflammatory cytokines like IL-1 and the subsequent disruption of iron homeostasis

Remarkably, supplementation with chemically synthesized selenomethionine sulfoxide to cultured HT1080 cells exerted anti-ferroptosis activity comparable to that of selenomethionine itself (Fig