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Next to NAD + precursors, modulation of NAD + -consuming enzymes showed promising results

& Tang, D

J Pharmacol Exp Ther 317:326333 Dickinson DA, Levonen AL, Moellering DR et al (2004) Human glutamate cysteine ligase gene regulation through the electrophile response element

however, most tissues contain vitamin C at much higher concentrations, ranging from 15 mM, and neurons contain vitamin C at concentrations of 10 mM or greater (Higdon et al