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Addressing these challenges will require interdisciplinary approaches and sustained efforts to optimize the properties of NDBs and streamline their development pipeline for clinical use (Arciola et al., 2018

For instance, although pathogenic mtDNA mutations impair cellular metabolism and cause cellular heterogeneity and disease, recent studies have unravelled that different mutations are associated with different clinical phenotypes and that purification choices of T cells also affect pathogenic mtDNA mutations in vivo , which has not been widely validated in RA and still needs to be further explored in the future (171)

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Oxygen-self-supplying and HIF-1-inhibiting coreshell nanosystem for hypoxia-resistant photodynamic therapy