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These disruptions can impair synaptic function by interfering with proper intracellular trafficking, signaling, and communication in neurons, contributing to the early pathology of sporadic AD (Marquer et al., 2014

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For example, miR-139 increases the radiosensitivity of NSCLC by directly targeting cJUN and KPNA2, disrupting the NRF2 pathway and amplifying radiation-induced lipid peroxidation (122)