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By promoting the accumulation of unfolded proteins in the endoplasmic reticulum, it induces increased expression of pro-inflammatory chemokines and aggravates the cellular stress response (Schurmann et al., 2014)

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This might be due to the change in the morphology of B-cell in the CF-M and CF-L groups (as the HP tissue structure has been damaged), which led to a decrease in the secretion of digestive enzymes compared to the ChF-M and ChF-L groups