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Sample Type(s): Human Umbilical cord Primary Cells (HUVECs), Abstract Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture: R

Studies in animal models of glaucoma and in isolated cells show that most glaucoma-relevant cell types (trabecular meshwork cells, retinal glia and RGCs) respond to pressure with fast onset electrical and calcium signals (~milliseconds to ~seconds), whereas sustained exposure to mechanical stressors tends to evoke phenotypes that are characteristic of glaucomatous injury

Huang J, Chen G, Wang J, Liu S, Su J

[12] had some methodological points of criticism