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Gel-shift assays show that single mutations (K23A or K25A) minimally affect rG4 binding, but the double K16-K17 mutation significantly impairs TERRA23 rG4 substrate binding (Fig

Despite the fundamental role of ER redox regulation in physiology and disease, the identity of ER glutathione transporters remains poorly defined

Consistent with these findings, our study demonstrated that celastrol upregulated NRF2 and GPX4 expression, reduced ROS accumulation, and inhibited ferroptosis

Uses of Maxiliv Injection Liver disease Benefits of Maxiliv Injection Liver disease Maxiliv Injection protects the liver from damage against harmful chemicals known as free radicals, thereby improving overall health of the liver