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Several strategies have been proposed to reduce or prevent OIPN, including alternating chemotherapy protocols to decrease the cumulative dose of oxaliplatin and combining with chemoprotectants

Large-scale deletions Large-scale deletions of mtDNA, generally referring to continuous losses of more than 500 base pair, have been increasingly acknowledged as hallmarks of mitochondrial genome instability in diverse human cancers [140]

Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system

Of the ePK there are 47 novel kinases: 17 SRPKLs (serine/arginine rich protein kinase-like), 6 PezKs (pezizomycotina kinases) and 24 unclassified kinases designated as Other