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Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dub syndrome

Upon reception of a signal to migrate such as chemical mediators called chemokines present near the edge of the wound the bound pool of actin monomers becomes immediately available to form actin filaments in the lamellipodium and filopodia of migrating cells