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High levels of circulating cortisol actively suppress the hypothalamus from releasing TRH and the pituitary from releasing TSH, leading to a central suppression of the entire thyroid system

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With the pandemic now characterized passed the acute phase, attention is shifting to post-acute sequelae of COVID-19 (PASC), is often referred to as 'long COVID' and possible preventative and therapeutic approaches are warranted (17,18)