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Specifically, metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with several extrahepatic comorbidities

[47] Phlebitis is particularly common in intravenous drug users, [48] and those undergoing chemotherapy, [49] whose veins can become sclerotic and difficult to access over time, sometimes forming a hard, painful "venous cord"

This results in energetically inefficient anaerobic glycolysis and defective tricarboxylic acid cycle, with sustained urinary excretion of pyruvate, orotate, citrate, -ketoglutarate, nitrogen-rich compounds and amino acids

In the next step, cell debri is removed by high speed centrifugation