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in fact, it plays a critical role in both systemic and peripheral tissue inflammation and triggers high levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-) or interleukin-1/6 (Il-1/6) that have been indicted as the main cytokines secreted by macrophages and adipose tissue [18], creating a not-favorable microenvironment that impairs adipose tissue stem cells (ASC) multilineage differentiation potential [19], viability, and apoptosis, as well as autophagy and mitophagy [20] as well as oxidative stress that impairs ASC immunomodulatory potential [21]

N., Drummond, G

doi: 10.1016/j.biomaterials.2014.08.020