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Recent clinical trials have reported that oral ALA is beneficial in improving multiple diseases, such as neuropathic pain, migraines, and diabetic neuropathy, and the safety of oral ALA in humans is well-documented 45,46,47

Prior studies have reported that the deletion of the IDH2 gene, one of the isoforms of isocitrate dehydrogenase, in ischemia-reperfusion injury (IRI) and cisplatin-induced acute kidney injury results in decreased NADPH levels, reduced GPX activity, and mitochondrial dysfunction in renal tubular cells [15,16,17]

Acetyl-L-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways