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However, human evidence remains limited

Subjects were administered 40 mg of labeled cholate (CA) orally, and blood CA concentrations analyzed at 20 and 60 min for these DuO parameters: systemic and portal hepatic filtration rates (HFRs), disease severity index (DSI), hepatic reserve (HR), and portal systemic shunt (SHUNT%)

290 , E1162E1171 (2006)

Research shows it affects 31.2% of human genes, upregulating genes involved in tissue repair, collagen synthesis, and blood vessel formation while downregulating inflammatory and tissue-destructive genes