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This mechanism prevents the replication of damaged DNA and serves as an essential barrier against cancer.9 Additionally, the p16INK4a-Rb pathway is activated in response to cellular stress, causing another form of cell cycle arrest, particularly in older cells.10 Telomere Shortening: Telomeres are repetitive DNA sequences at the ends of chromosomes that protect them from damage and prevent the loss of genetic material during cell division.11 However, each cell division results in the shortening of telomeres

Del Viscovo, A

10.1073/pnas.1913904117 Proc

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