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doi:10.1073/pnas.0803391105 91

Hyperphosphorylation of tau results in disassociation of tau from microtubules, translocation to dendrites within neurons, oligomerization and the generation of intracellular NFTs

By performing a GFP-Trap SUMOylation assay we found that TDP-43 PYNLS rescues the loss of SUMOylation observed when expressing TDP-43 NLSmut indicating that nuclear localization, and not the lysine (K) residues within the NLS, is required for stress-dependent TDP-43 SUMOylation (Fig