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Description

Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H

66 FuS.KurzrockR

FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22

Consequently, its activity is a critical determinant for cellular and organismal physiology, while its dysregulation is commonly linked to human aging and age-related disease