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To enhance interpretability despite this variability, we pooled outcomes within instruments (HDRS, BDI, MADRS), conducted prespecified subgroup analyses by comparator group and age, used random-effects models, performed leave-one-out sensitivity analyses and publication-bias diagnostics, and applied meta-regression to examine treatment duration and daily dose

Additional hurdles include the risk of off-target effects in mtDNA or the nuclear genome, potential immune responses to the editing machinery, and substantial technical and regulatory barriers that complicate translation of in vivo gene editing into clinical practice

Recently, lactylation has garnered research interest for its potential link to AD

Type 2 diabetes mellitus is characterized by chronic hyperglycemia resulting from insulin resistance, amyloid deposition, pancreatic -cell dysfunction, and impaired glucose regulation (371, 372)