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Data are presented as means 95% confidence intervals (CIs) unless otherwise stated

The coordinates and geometric restraints for each inhibitor were created from smiles using Grade 49 with the qm+mogul option

TMTpro-18plex: the expanded and complete set of TMTpro reagents for sample multiplexing

Existing evidence points toward melatonins role as an antioxidant showing systemic therapeutic benefits in PD-relevant clinical trials (dyskinesia, sleep disorder) 187 , which combined with amphiphilic nature allowing for BBB diffusion further encourages therapeutic focus revisiting melatonin as a mitophagy agonist with NF-B and Nrf2 activating effect mentioned prior 187