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The scope and applicability of the developed method are demonstrated through the targeted metabolomic profiling of A549 human lung adenocarcinoma cells under heavy metalinduced oxidative stress, providing detailed insights into chemically induced metabolic alterations

However, as an individual treatment and in combination with other antineoplastic medicines, curcumin has demonstrated promising effects in the treatment of several cancers: It has an impact on several signaling pathways and can therefore successfully alter both the initiation and progression of certain cancers (Zoi et al., 2021)

Among the genes downregulated in response to GSTO1 siRNA, coagulation factor III ( F3 ), thrombospondin 1 ( THBS1 ), cysteine-rich angiogenic inducer ( CYR61 ) and bone morphogenetic protein 4 ( BMP4 ), related to blood coagulation and blood vessel morphogenesis, were markedly decreased (Supplementary Table 11)

International, multicenter standardization of acute graft-versus-Host disease clinical data collection: A report from the mount Sinai acute GVHD international consortium