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This dimerization appears to induce a switch in intracellular signaling cascades in which administration of a dopamine agonist (quinpirole) alone leads to a rapid increase in Ca 2+ levels, an effect not observed in preparations expressing D2R in the absence of GHSR1a (Kern et al., 2012)

Dichtel LE, Corey KE, Haines MS, Chicote ML, Lee H, Kimball A, et al

PET scans may be performed to detect distribution of the targeting systems either on the subject in vivo, including changes in those distributions over time, or on excised samples of the subject