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It highlights a broader principle: many of these foundational molecules have complex, sometimes paradoxical roles

[161] Older adults typically have reduced endogenous melatonin production and may benefit from supplementation, but they may also be more susceptible to side effects

This indicates that MODA by itself does not induce hepatocellular injury

Chronic oral vitamin C supplementation (500 mg/day for 30 days) exerted no significant influence on FMD within any of the groups, and endothelium-independent dilation responses remained invariant across all groups and interventions (54)