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Vitamin B12 is generally considered safe, even at high doses, because it is water-soluble and excess amounts are excreted in urine

Direct comparison is imperfect because the trials enrolled different populations, ran for different durations, and used different primary endpoints

Pinto LC, Falcetta MR, Rados DV, Leitao CB, Gross JL

What Chronic Illness Looks Like Through a Repair Lens The patients who have shaped my thinking about these compounds most are not the ones with straightforward injuries or clean diagnoses