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Procedures This study was a double-blind, randomized, placebo controlled trial where participants were placed into one of two groups randomly by blocks of two, controlling for sex and running time (clinicaltrials.gov identifier: NCT02172625, and S1 Checklist)

doi: 10.1371/journal.pone.0152126 67

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Utilizing MSC-derived exosomes to encapsulate drugs as a nanoparticulate formulation offers several potential advantages over traditional nanoparticle-based approaches, including improved biocompatibility and reduced immunogenicity, enhanced targeting capabilities, and an increased ability to traverse biological barriers such as the BBB [105, 106]