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More recently FB1, FB2 and FB3 were observed in samples from a small mixed cohort and a cohort in rural Ethiopia (Martins et al

38 In PD and HD, pro-apoptotic proteins such as BCL2-associated X (BAX)and p53 upregulated modulator of apoptosis (PUMA) are upregulated, while anti-apoptotic factors like B-cell lymphoma 2 (BCL-2) are downregulated, tipping the balance toward cell death

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For example, its serves as a cellular substrate to the hepatitis C virus NS3-4A protease (28), and ectopic expression of GPX8 in the rat pancreatic -cells induces ER stress (29)