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TLR4 can activate the NLRP3 inflammasome and cause microglial pyroptosis in SCI mouse models via the Janus kinase 2/signal transducer and activator of transcription 1/dead-box helicase 3 X-linked/NLRP3 signaling pathway (Wang et al., 2022b)

More recently, an in vitro study showed that SARS-CoV-2 viroporin protein induces the NLRP3-inflammasome formation in a lung epithelial cell line (95), suggesting that SARS-CoV-2 may trigger ROS-mediated NLRP3-inflammasome activation similarly to SARS-CoV

421 Research, primarily using experimental models of mechanical nerve damage, has explored the mechanisms underlying neuropathic pain, revealing increased excitation and facilitation of pain signals, along with a loss of inhibition in both the PNS and the CNS

Second, the number of M1like macrophages was not altered by eosinophil depletion, but decreased in mice receiving IL4c (Fig 6E)