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To fully abrogate any possible RBR-residing catalytic activity of ANKIB1, we next expressed mutant ANKIB1 lacking the entire RBR (ANKIB1RBR) in ANKIB1-KO cells (Extended Data Fig

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LM22A-4 LM22A-4 is a tripeptide mimetic identified through in silico screening using a pharmacophore model based on BDNF loop domains

These results suggested that GGT was the most important enzyme responsible for GSH degradation and that deletion of both ggt and pepT could significantly suppress the GSH degradation