glutathione mtorc2 Full article: A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis mTOR signaling networks: mechanistic insights

[DOI] [Google Scholar] Tian, Y

Interestingly, Cys412 is conserved in human and mouse [75] but not in most land plants, although it forms a regulatory disulfide with Cys278 in CrPGK1 [81]

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One of the key factors responsible for apoptotic induction downstream of ER stress is the CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP)