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The majority of the measured cytokines were detected in both groups, such as IL-1, IL-6, IL-8, IL-10, TNF-, IP-10, IFN-, IFN-1, and IFN-2/3, although their levels were unchanged in all analysed conditions ( Figures 3AI )

Also, vitamin C, selenium, alpha lipoic, broccolli seed extract, curcumin, resveratrol, grape seed extract, quercetin, milk thistle seed extract, cordyceps, black pepper, aloe leaf are present to complement this effort [40]

Moreover, studies reported that EVs derived from curcumin [269] can activate the AMPK-SIRT1-LXR pathway in foam cells, which in turn upregulates ABCA1 and promotes cholesterol efflux [270]

T.OzhimuthuA.Panneer SelvamS.et al