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In general, CSE is more highly expressed than CBS in peripheral organs, including the liver and kidney, with a ratio of about 60:1 in the liver and about 20:1 in the kidney [129]

doi: 10.3389/fendo.2024.1466775 Received 18 July 2024 Accepted 15 November 2024 Published 10 December 2024 Volume 15 - 2024 Edited by ke Sjholm, Gvle Hospital, Sweden Reviewed by Zhen Geng, Shanghai University, China Sanjiv Neupane, Stony Brook University, United States Updates Copyright 2024 Jia, Zhang and Yu

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Conclusion: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients