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Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pacock J, et al

P53, a tumor suppressor, has been reported to inhibit cystine uptake and sensitize cells to ferroptosis by downregulating the expression of SLC7A11[88]

Mechanistic studies showed that I-S1 crosses the blood-brain barrier by adsorptive transcytosis and that murine ACE2 is involved in brain and lung uptake, but not in kidney, liver, or spleen [52] (Fig