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Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

Step therapy Some United Healthcare plans require patients to try first-line diabetes medications, like metformin, before approving Ozempic

In contrast, consuming too much calcium can prevent the body from absorbing enough magnesium

Using an alcohol swab or pad, clean a two-inch area around the site you have chosen