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[PMC free article: PMC5444000] [PubMed: 28584816] 196

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A recent assessment of liver cirrhosis mortality led to a global estimate of just over one million deaths in 2010 which was approximately 2 % of all deaths [3, 103]

In contact dermatitis and atopic dermatitis, inhibition of 15-LOX inhibits podosome formation in dendritic cells, downregulates the antigen uptake and cell migration capabilities, and contributes to the alleviation of skin inflammation (Figure 2)