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H-MESO-1 cells treated with TS (structure shown in Supplementary Fig

The conjugation of compounds that could facilitate active transport across BBB is necessary, as they cannot passively diffuse through the BBB for applications in neuro nanomedicine [237]

doi: 10.1186/s43014-023-00112-1 44

Thus, it was not possible to assess the ROS production in these cells but PAP was capable to increase ROS production in shorter time periods (data not shown)