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Thus, membrane lipid peroxidation disrupts the organization of the ETC, leading to electron leak and ROS production (Paradies et al., 2019)

Similarly, Ginkgolide B (GB), a key monomers of Ginkgo biloba extract, reduced NAFLD in mice fed a high-fat diet, and the WB results revealed the expression levels of ferroptosis-related proteins such as Nrf2, GPX4, HO-1, TFR1, and ferritin heavy chain-1 (FTH1) in vitro and in vivo

The expanded Enterobacteriaceae release LPS, activating the TLR4/MyD88 axis to upregulate epithelial NOX1 expression, thereby driving secondary ROS bursts that amplify epithelial barrier disruption and inflammatory cascades [404]

J Toxicol Environ Health Crit Rev