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Nevertheless, our correlative human tissue data, together with our mechanistic in vitro cellular data with GrK and endothelial cells, support a model in which extracellular GrK can dampen angiogenesis and thereby reduces tumor growth

Amongst these alterations, the metabolic switch from FA utilization to carbohydrate metabolism, which consumes less oxygen to produce ATP, has extensively been described in the last decades [125,126]