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aureus highlights the pressing need for further research into the systematic changes that occur in this species in response to antibiotic stress

While the real-world data of DAA therapy for chronic hepatitis C have been reported mostly from western countries [14,15,16,17,18,19,20,21,22], there is a paucity of Asian data concerning DAAs [23,24,25,26,27]

Pharmaceutical agents such as Cox-2 inhibitors, thalidomide, megestrol, medroxyprogesterone acetate, melatonin, and DCA, and supplemental nutrients or antioxidants from food [35], such as -3 poly-unsaturated fatty acids, vitamin C, vitamin D, vitamin E, -hydroxy--methylbutyrate (HMB) [36] and lycopene, represent potential anti-cachexia treatments that are being explored in clinical trials

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