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Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid

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Excessive H 2 O 2 reacts with the Fe 2+ in cells to generate a large number of ROS through Fenton reactions, which promote the generation of intracellular LPOs and trigger ferroptosis