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In most healthy cells, this ratio is maintained in a highly reduced state between 30:1 and 100:1

E.RichterL.YachechkoR.PyleA

doi: 10.1111/jfbc.14398 53

However, compared with humans, the ratio of the oral dose to the serum concentration seems to be higher in rats than in humans, making it difficult to directly apply relevant studies to humans (Meftah et al., 2021)