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These doses are approximately 1.4 and 0.04 times, respectively, the human topical dose of clobetasol propionate ointment

doi: 10.1038/s41514-023-00124-2

By supplementing with vitamin B3, the Walsh approach suggests that the activity of COMT can be increased, helping to break down excess dopamine and norepinephrine and reducing symptoms of anxiety and hyperactivity