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Moreover, a slight reduction in the inhibitory ability was observed when residue M44 was substituted with alanine

Hellinger R, Sigurdsson A, Wu W, Romanova EV, Li L, Sweedler JV

RSV was subsequently reported to increase phosphorylation of Akt and transcriptional activity of PPAR in the aorta of wild-type mice, thus supporting the hypothesis of SIRT1-PPAR interaction, and to strongly decrease LPC-induced mitochondrial ROS in the aortic endothelium of C57BL/6 mice ( Because of the pleiotropic actions of RSV, clinical trials are currently testing its therapeutic potential in a wide range of human diseases