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In PTSD mice models, trauma exposure increased tyrosine hydroxylase expression (the rate-limiting enzyme in catecholamine biosynthesis), elevating stress hormones epinephrine and norepinephrine in serum and colon, which upregulated claudin-2 expression, confirming gut barrier dysfunction (Yadav et al., 2023)

However, the biochemical pathways linking catabolism to ER function are not known

doi: 10.1111/j.1749-6632.2002.tb04690.x [DOI] [PubMed] [Google Scholar] 10.Ellman G.L.1959