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Figure 2 2.2.1 CD8+ T cells CD8+ T cells, key immune effector cells in the TME, are involved in tumor clearance, as well as in responding to viral infections and other pathological conditions (56)

Briefly, for mammalian-expressed PV VLPs, PV-specific gene sequences for the P1 region were codon optimised for expression in mammalian cells and cloned into modified vaccinia virus Ankara (MVA) transfer vectors upstream of an uncleavable 3CD sequence derived from PV1 Mahoney with native sequence