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doi: 10.1016/j.bbr.2011.05.037

Each of these conditions can be classified as primary or secondary, depending on the origin of the dysfunction

As a side note, cest2.2 O/E nematodes also had slightly less ORO staining in the hindgut when compared to wt ones (Fig 4E and F), though the effect was not as pronounced as the effect of CEST2.2 O/E in the context of complex I deficiency (Fig 4AC)