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Absorption, transport and tissue distribution The seminal identification of a mammalian membrane transporter for ergothioneine by Grundemann and colleagues in 2005 (Reference Grndemann, Harlfinger and Golz24) provided a mechanism by which ergothioneine is acquired from the diet, and further evidence for an essential role for ergothioneine in vivo

Metabolic regulation of redox balance in ageing Redox reactions occur throughout the cellular metabolism with the production of a small number of reactive oxygen radicals

Silencing the expression of the endogenous ATF4 showed the opposite results (Figure 5A)

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