mechanism of action of bpc-157 BPC-157: mechanism, in vitro studies, and gaps in human evidence BPC-157 vs TB-500: Complete Comparison

The non-dairy treats will be available at the Astor Place, Midtown East, Harlem, Upper East Side and Battery Park City Shacks for a limited time and are part of Shake Shacks efforts to include more sustainably sourced menu items

0.1% (placebo) Steady State: Achieved after 4-5 weeks of weekly dosing Safety: Nausea (68% at 4.5 mg), vomiting (32%), generally mild-moderate and transient Discontinuation: 14% discontinued due to GI adverse events Appetite Effects: Significant reductions in Visual Analogue Scale (VAS) hunger scores Publication: Lau DCW, et al

Start with 0.5% to 1% regardless of wrinkle severity to establish tolerance

Stopping treatment may allow gradual return to pre-treatment patterns